(Srila Prabhupada in Vrindavan, 1977)
Prabhupāda: So we, in our childhood, we had to study that small book, Cāṇakya Śloka. So in that principles of morality even Cāṇakya Paṇḍita says that sannimitte varaṁ tyāga vināśe niyate sati. Vināśe niyate sati: "Oh, this body, this body is destined to be destroyed. You cannot protect it. It is to be destroyed." Sannimitte varaṁ tyāge vināśe. Vināśe means it is sure to be destroyed. "As sure as death." There is nothing sure as death. Therefore this body should be utilized, sannimitte, for purpose of spiritual realization. Before it is finished... In all the śāstras, this is the advice. This is the advice. The dog's body will be finished, and the man's body will be finished, but what is the difference of dog and man? The dog does not know how to utilize his body, but we are given instruction in so many books of knowledge, how to utilize this body.
So Cāṇakya Paṇḍita says that sannimitte varaṁ tyāga. You have to give up this body. Why don't you give it up for the highest cause? Highest cause. This is the highest cause, spiritual realization. Somebody's offering his body for country's cause. Somebody's offering body for the society's cause. Or somebody's offering body for theft case or some murdering case. We have, everyone has to offer his body at the end. But the man who sacrifices this body for the purpose of self-realization, he's the most intelligent man.
(Srila Prabhupada Lecture, New York, April 5, 1966)